Expression and cyclic variations of catechol-O-methyl transferase in human endometrial stroma
نویسندگان
چکیده
منابع مشابه
Catechol-O-methyl transferase and schizophrenia.
Catechol-O-methyl transferase (COMT) is an enzyme involved in the degradation of dopamine. The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT enzyme activity. It is particularely important in prefrontal cortex, since COMT activity is the most important regulator of the prefrontal dopamine function. Gi...
متن کاملMethionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity.
Catechol-O-methyl transferase (COMT) plays a key role in the degradation of brain dopamine (DA). Specifically, low COMT activity results in higher DA levels in the prefrontal cortex (PFC), thereby reducing the vulnerability for attentional and cognitive deficits in both psychotic and healthy individuals. COMT activity is markedly reduced by a non-synonymous single-nucleotide polymorphism (SNP) ...
متن کاملCharacterization of a novel human catechol-O-methyl-transferase mutant with triplet point mutations.
Human catechol-O-methyltransferase (COMT, EC 2.1.1.6) catalyzes the transfer of the methyl group to a variety of endogenous and exogenous catechol substrates using S-adenosyl-L-methionine as the methyl donor. This enzymatic O-methylation plays an important role in the inactivation of biologically-active and toxic catechols. A number of studies in recent years have sought to characterize the pol...
متن کاملassociation of catechol-o-methyl transferase gene polymorphism with prostate cancer and benign prostatic hyperplasia
background : a single nucleotide variation within atechol-o-methyl transferase (comt) gene may alter the comt enzyme activity level. polymorphism of val158met in the comt gene has been related to malignancy. in this regard, a study was carried out to find a possible association between the comt gene polymorphism in patients with sporadic prostate cancer (pca) and benign prostatic hyperplasia (...
متن کاملCatechol-o-methyl Transferase and Monoamine Oxidase Activity in the Ocular Tissues of Albino Rabbits.
The distribution of catechol-O-methyl transferase and monoamine oxidase activity in the ocular tissues of albino rabbits has been determined with a radioactive tracer assay. The distribution of the former varied in the different tissues within a restricted range whereas the distribution of monoamine oxidase activity exhibited larger variations. Sympathetic denervation did not appear to affect c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2008
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2007.01.042